(I) To start using PROBE, you must first upload a multiple alignment: Either upload a sequence alignment file (in FASTA format): Example of a valid FASTA alignment file Or upload previous PROBE results (in XML format): Example of a valid XML PROBE file (II) In addition to the alignment, you can choose to use your own phylogenetic tree for visualization: Upload a phylogenetic tree file (in Newick format): Example of a valid Newick tree file